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Previous versions include Excel 2016, Excel 2013, Excel 2010, Excel 2007, and Excel 2003.

As well as with Microsoft Excel, XLSX files can be opened using various other programs, including Google Sheets, LibreOffice, and Apple Numbers. Microsoft Excel with a Microsoft 365 subscription is the latest version of Excel. This also means that XLSX files can present larger data sets and have a greater range of cells. Whereas XLS files hold data in a single file, XLSX saves data in the Open XML format, with separate files zipped up together to reduce space. The main difference between XLSX and XLS is in how the data is stored. XLSX files are very similar in their functionality to their predecessor, XLS they can be used to create spreadsheets, charts and graphs, process mathematical formulae, and to share or analyse data.

XLSX was developed by Microsoft as part of their Office 2007 development and is now the default file format for Excel. This file format is a zipped Open XML-based file type, meaning it compresses or reduces the file size so that it can access stored data faster and be easily shared with other programs.

XLSX is a file type created using Microsoft Excel - part of the Microsoft Office Suite software.